Cover Letter No. 2

Dear Dr. Jonhson:

We are submitting our manuspcrit entitled "Pharkamcokinetics of imipenem in patients recieving high-volume hemofiltration" for publication consideration in Tangamandapio Journal.
This study describes how high-volume hemofiltration is affecting plasma concentrations of imipenem, indicating that critically ill patients need special dosage adjustment to ensure effectiveness of antibiotic therapy. We propose a mathematical model to administrate the correctly dose of imipenem when patients recieve this type of hemofiltration.

This article has not been submitted for publication elsewhere and the authors declare no conflict of interest.

Yours sincerely,

Leslie Escobar O.
PhD student of Pharmaceutical Sciences
Universidad de Chile
lescobar@ciq.uchile.cl

Cover Letter No. 1

Dear Dr. Jonhson:

I have enclosed our manuspcrit entitled "Pharkamcokinetics of imipenem in patients recieving high-volume hemofiltration" for a possible publication in your prestigious journal.
This study was my PhD thesis and was conducted to try to understand how this new technique (wich is now increasingly used in septic patients) affects the plasma concentrations necessary to ensure effectiveness of antibiotics, giving an approximation of the clinical consequences this might implicate in these patients.

I would like to tell the present article has not been submitted for publication elsewhere and the authors declare no conflict of interest.
We would be pleasure to give you any information that you might request.

Yours sincerely,

Leslie Escobar O.
PhD student of Pharmaceutical Sciences
Universidad de Chile
lescobar@ciq.uchile.cl